It is an interesting topic, too! Nice to have an etiquette one.
Some other answers to specific questions, at least, my own thoughts:
Is it appropriate to wait things out to observe conditions prior to making a decision?
Yes. In fact, I wouldn't even tell them I was waiting to decide; I'd just wait. I'd plug in a reminder on my calendar for a week before the event, and then I'd decide them, and RSVP.
Should I assume that a mask will be required?
I think you should assume that any official restrictions or recommendations will be honored. And that all guests should be prepared to wear a mask.
If you don't want to attend unless other people ARE wearing masks, that would be a question I'd ask the hostess before deciding: "It's important to me to be safe, so I'm wondering if you know whether people will be wearing masks."
If she says no, you can decline at that point.
If she says she thinks so or doesn't know, you can decide if you want to risk it. And if you arrive and there are not enough people wearing masks to keep you comfortable, you can give greetings at the door, wave a cheery goodbye, say "Sorry not to stay--I'm taking extra precautions, so I'm going to leave, but I hope you have a great time. Happy baby/wedding!"
(What if I am wearing one and others are not?)
You can decide whether you want to leave or stay. I'm torn on whether you can ask people to wear masks. My vote would be to just leave instead; let them live with the consequence of not wearing the mask, and see if other people will make your point for you. (Sort of like, if you post something here, and people are arguing with you, it's a good idea to just wait and see if others will take up your cause.)
If rates spike closer to the party is it appropriate to cancel (guest or host)?
Yes. Because safety trumps etiquette. Even before a sometimes-deadly, often-unpleasant easily spread virus, you could cancel because you are unwell.
You don't have to go into a lot of stuff; you can just say, "I'm not feeling well, so I won't be able to attend." If you want, you CAN say, "I'm going to drop off the gift and wave from my car; I want to stay safe, and the surge in cases has me cautious."